Publications

1998:

• Verstegen, M.M.A., Van Hennik, P.B., Terpstra, W., Van Den Bos, C., Wielenga, J.J., Van Rooijen, N., Ploemacher, R.E., Wagemaker, G. and Wognum, A.W., 1998. Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells. Blood. vol. 91. pp. 1966-1976. (#165)



• Wijburg, O.L.C., Van den Dobbelsteen, G.P.J.M., Vadolas, J., Sanders, A., Strugnell, R.A. and Van Rooijen, N., 1998. The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens. Eur. J. Immunol.. vol. 28. pp. 479-487. (#164)



• Straub, R.H., Dorner, M., Riedel, J., Van Rooijen, N., Lang, B., Scholmerich, J. and Falk, W., 1998. Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen is mediated by opioidergic transmission. Am. J. Physiol.. vol. 43. pp. R997-R1003. (#163)



• Van Rooijen, N., 1998. Liposomes. In: Encyclopedia of Immunology (Second Edition). Eds. I.M. Roitt and P.J. Delves. Academic Press Ltd. London, UK.. pp. 1588-1592. (#162)



• Van Rooijen, N. and Sanders, A., 1998. Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine: Synergistic and antagonistic effects of liposomal phospholipids and drugs. Int. J. Pharmaceut.. vol. 162. pp. 51-58. (#161)



• Van Rooijen, N. and Sanders, A., 1998. The macrophage as target or obstacle in liposome-based targeting strategies. Int. J. Pharmaceut.. vol. 162. pp. 45-50. (#160)

1997:

• Wijburg, O.L.C., DiNatale, S., Vadolas, J., Van Rooijen, N. and Strugnell, R.A., 1997. Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during Influenza virus infection. J. Virol.. vol. 71. pp. 9450-9457. (#159)



• Wijburg, O.L.C., Heemskerk, M.H.M., Boog,C.J.P. and Van Rooijen, N., 1997. Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59. Immunology. vol. 92. pp. 252-258. (#158)



• Terpstra, W., Leenen, P.J.M., Van den Bos, C., Prins, A., Loenen, W.A.M., Verstegen, M.M.A., Van Wijngaardt, S., Van Rooijen, N., Wognum, A.W., Wagemaker, G., Wielenga, J.J. and Lowenberg, B., 1997. Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes. Leukemia. vol. 11. pp. 1049-1054. (#157)



• Sekine, Y., Bowen, L.K., Heidler, K.M., Van Rooijen, N., Brown, J.W., Cummings, O.W. and Wilkes, D.S., 1997. Role of passenger leukocytes in allograft rejection: Effect of depletion of donor alveolar macrophages on the local production of TNF-a, Th1/Th2 cytokines, IgG subclasses and pathology in a rat model of lung transplantation. J. Immunol.. vol. 159. pp. 4084-4093. (#156)



• Pena-Rossi, C., Delcroix, M., Huitinga, I., McAllister, A., Van Rooijen, N., Claassen, E., Brahic, M., 1997. Role of macrophages during Theiler's virus infection. J. Virol.. vol. 71. pp. 3336-3340. (#155)



• Hirunpetcharat, C., Tian, J.H., Kaslow, D.C., Van Rooijen, N., Kumar, S., Berzofsky, J.A., Miller, L.H. and Good, M.F., 1997. Complete protective immunity induced in mice by immunization with the 19kDa carboxylterminal fragment of the merozoite surface protein-1 (MSP119) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: Correlation of protection with antigen-specific a. J. Immunol.. vol. 159. pp. 3400-3411. (#154)



• Gaytan, F., Bellido, C., Aguilar, R., Morales, C., Van Rooijen, N. and Aguilar, E., 1997. Role of the testis in the response of the pituitary-testicular axis to NO-related agents. Eur. J. Endocrinol.. vol. 137. pp. 301-308. (#153)



• Feith, G.W., Bogman, M.J.J.T., Assmann, K.J.M., Van Gompel, A.P.M., Schalkwijk, J., Van Rooijen, N., Koene, R.A.P., 1997. Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN dependent anti-GMB nephritis in mice. Exp. Nephrol.. vol. 5. pp. 301-304. (#152)



• Ciavarra, R.P., Buhrer, K., Liuzzi, F.J., Van Rooijen, N., Tedeschi, B., 1997. T Cell priming against vesicular stomatitis virus analyzed in situ: I. Red pulp macrophages but not marginal metallophilic or marginal zone macrophages are required for priming CD4+ and CD8+ T cell.. J. Immunol.. vol. 158. pp. 1749-1755. (#151)



• Nieuwenhuijzen, G.A.P., Knapen, M.F.C.M., Hendriks, T., Van Rooijen, N., Goris, R.J.A., 1997. Elimination of various subpopulations of macrophages and the development of the multiple organ dysfunction syndrome in mice. Arch. Surgery. vol. 132. pp. 533-539. (#150)



• Van Andel, R.A., Hook, R.R., Franklin, C.L., Besch-Williford, C.L., Van Rooijen, N., Riley, L.K., 1997. Effects of neutrophil, natural killer cell and macrophage depletion on murine Clostridium piliforme infection. Infect. Immunity. vol. 65. pp. 2725-2731. (#149)



• Wijburg, O.L.C., DiNatale, S., Strugnell, R.A., Van Rooijen, N., 1997. The role of alveolar macrophages in induction of primary cytotoxic T lymphocyte responses during influenza virus infection. In: "Mucosal solutions: advances in mucosal immunology" Eds. AJ Husband, KW Beagley, RL Clancy, AM Collins, AW Cripps, DL Emery, University of Sydney, ISBN 1 86451 289 X. . vol. 1. pp. 289-300. (#148)



• Salkowski, C.A., Detore, G., McNally, R., Van Rooijen, N., Vogel, S.N., 1997. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: The roles of macrophages, endogenous IFN-g and TNF receptor-1-mediated signaling. J. Immunol.. vol. 158. pp. 905-912. (#147)



• Espenes,A., Press, C.McL., Van Rooijen,N., Landsverk,T., 1997. Apoptosis in phagocytic cells of lymphoid tissues in rainbow trout (Oncorhynchus mykiss) following administration of clodronate liposomes. Cell Tissue Res.. vol. 289. pp. 323-331. (#146)



• Chung, Y.H., Jun, H.S., Kang, Y., Hirasawa, K., Lee, B.R., Van Rooijen, N. and Yoon, J.W., 1997. Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats. J. Immunol.. vol. 159. pp. 466-471. (#145)



• Zysk, G., Bruck, W., Huitinga, I., Fischer, F.R., Flachsbarth, F., Van Rooijen, N., Nau, R., 1997. Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis. J. Neuroimmunol.. vol. 73. pp. 77-80. (#144)



• Samson, J.N., Annema, A, Groeneveld, P.H.P., Van Rooijen, N., Langermans, J.A.M., Van Furth, R., 1997. Elimination of resident macrophages from the livers and spleens of immune mice impairs acquired resistance against a secondary Listeria monocytogenes infection. Infect. Immun.. vol. 65. pp. 986-993. (#143)



• Sundstedt, A., Hoiden, I., Rosendahl, A., Kalland, T., Van Rooijen, N., Dohlsten, M., 1997. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol.. vol. 158. pp. 180-186. (#142)



• Rudnicka, W., Wieckowska, M., Van Rooijen, N., Rozalska, B., 1997. The immune response to staphylococcal antigens in mice depleted of macrophages by Cl2MDP-liposomes. Zentralblatt fur Mikrobiologie. vol. 286. pp. 511-522. (#141)



• Reinders, M.E., Van Wagensveld, B.A., Van Gulik, T.M., Corssmit, N.P.M., Frederiks, W.M., Chamuleau, R.A.F.M., Van Rooijen, N., Obertop, H., 1997. No attenuation of ischemic and reperfusion injury in Kupffer cell-depleted, cold preserved rat livers. Transplantation. vol. 63. pp. 449-454. (#140)



• Worgall, S., Leopold, P.L., Wolff, G., Ferris, B., Van Rooijen, N., Crystal, R.G., 1997. Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. Human Gene Therapy. vol. 8. pp. 1675-1684. (#139)



• Wolff, G., Worgall, S., Van Rooijen, N., Song, W-R., Harvey, B-G., Crystal, R.G., 1997. Enhancement of in vivo Adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J. Virol.. vol. 71. pp. 624-629. (#138)



• Leenen, P.J.M., Voerman, J.S.A., Radosevic, K., Van Rooijen, N., Van Ewijk, W., 1997. Mouse spleen dendritic cells: phagocytic activity and expression of macrophage markers. Adv. Exp. Med. Biol.. vol. 417. pp. 91-95. (#137)



• Leenaars, P.P.A.M., Savelkoul, H.F.J., Hendriksen, C.F.M., Van Rooijen, N., Claassen, E., 1997. Increased adjuvant efficacy in stimulation of antibody responses after macrophage elimination in vivo. Immunology. vol. 90. pp. 337-343. (#136)



• Broekhuyse, R.M., Huitinga, I., Kuhlmann, E.D., Van Rooijen, N., Winkens, H.J., 1997. Differential effect of macrophage depletion on two forms of experimental uveitis evoked by pigment epithelial membrane protein (EAPU), and by melanin-protein (EMIU). Exp. Eye Res.. vol. 65. pp. 841-848. (#135)



• Van Rooijen, N. and Sanders, A., 1997. Elimination, blocking and activation of macrophages: three of a kind? J. J. Leuk. Biol.. vol. 62. pp. 702-709. (#134)



• Van Rooijen, N., Bakker, J., Sanders, A., 1997. Transient suppression of macrophage functions by liposome-encapsulated drugs. Trends Biotechnol.. vol. 15. pp. 178-185. (#133)

1996:

• Blok, W.L., De Bruijn, M.F.T.R., Leenen, P.J.M., Eling, W.M.C., Van Rooijen, N., Stanley, E.R., Buurman, W.A., Van Der Meer, J.W.M., 1996. Dietary n-3 fatty acids increase spleen size and post-endotoxin circulating tumor necrosis factor in mice: role of macrophages, macrophage precursors, and Colony Stimulating Factor-1. J. Immunol.. vol. 157. pp. 5569-5573. (#132)



• Suda, T., Callahan, R.J., Wilkenson, R.A., Van Rooijen, N., Schneeberger,E.E., 1996. Interferon-g reduces Ia+ dendritic cell traffic to the lung. J. Leuk. Biol.. vol. 60. pp. 519-527. (#131)



• Hu, Q., Van Rooijen, N. and Liu, D., 1996. Effect of macrophage elimination using liposome-encapsulated dichloromethylene diphosphonate on tissue distribution of liposomes. J. Liposome Research. vol. 6. pp. 681-698. (#130)



• Van Lent,P.L.E.M., Holthuyzen,A.E.M., Van Den Bersselaar,L.A.M., Van Rooijen,N., Joosten, L.A.B., Van De Loo,F.A.J., Van De Putte,L.B.A. and Van Den Berg,W.B., 1996. Phagocytic lining cells determine local expression of inflammation in collagen type II arthritis. Arthritis Rheum.. vol. 39. pp. 1545-1555. (#129)



• Van Klink,F., Taylor,W.M., Alizadeh, H., Jager, M.J., Van Rooijen, N. and Niederkorn, J.Y., 1996. The role of macrophages in Acanthamoeba keratitis. Invest. Ophthalm. Vis. Sci.. vol. 37. pp. 1271-1281. (#128)



• Karupiah,G., Buller,R.M.L., Van Rooijen,N., Duarte,C.J. and Chen,J., 1996. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J. Virol.. vol. 70. pp. 8301-8309. (#127)



• Wijburg, O.L.C., Heemskerk, M.H.M., Sanders, A., Boog,C.J.P. and Van Rooijen, N., 1996. Role of virus specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection. Immunology. vol. 87. pp. 34-41. (#126)



• Gaytan, F., Bellido, C., Morales, C., Garcia, M., Van Rooijen, N. and Aguilar, E., 1996. In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects. J. Endocrinol.. vol. 150. pp. 57-65. (#125)



• Ben-Nathan, D., Huitinga, I., Lustig, S., Van Rooijen, N. Kobiler, D., 1996. West-Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice. Arch. Virol.. vol. 141. pp. 459-469. (#124)



• DeHaan, A., Groen, G., Prop, J., Van Rooijen, N., Wilschut, J., 1996. Mucosal immunoadjuvant activity of liposomes: Role of alveolar macrophages. Immunology. vol. 89. pp. 488-493. (#123)



• Buiting,A.M.J., Zhou,F., Bakker,J.A.J., Van Rooijen,N. and Huang,L., 1996. Biodistribution of clodronate and liposomes used in the liposome mediated macrophage "suicide" approach. J. Immunol.. vol. 192. pp. 55-62. (#122)



• Buiting,A.M.J., De Rover,Z., Kraal,G., Van Rooijen,N., 1996. Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen. Scand. J. Immunol.. vol. 43. pp. 398-405. (#121)



• Boelen,A., Platvoet-ter Schiphorst,M.C., Van Rooijen,N., Wiersinga,W.M., 1996. Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse. Eur. J. Endocrinol.. vol. 134. pp. 513-518. (#120)



• Bayon,L.G., Izquierdo, M.A., Sirovich,I., Van Rooijen,N., Beelen,R.H.J. and Meijer,S., 1996. Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver. Hepatology. vol. 23. pp. 1224-1231. (#119)



• Van Rooijen,N., Wijburg,O.L.C., Van Den Dobbelsteen, G.P.J.M. and Sanders, A., 1996. Macrophages in host defense mechanisms. In: "Immunology of silicones", M.Potter & N.R.Rose eds.Springer-Verlag, Berlin; Curr. Top. Microbiol. Immunol.. vol. 210. pp. 159-165. (#118)



• Van Rooijen,N., Sanders,A., Van den Berg,T., 1996. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of drugs. J. Immunol. Meth.. vol. 193. pp. 93-99. (#117)



• Van Rooijen,N., Sanders,A., 1996. Kupffer cell depletion by liposome-delivered drugs: Comparative activity of intracellular clodronate, propamidine and ethylenediaminetetraacetic acid (EDTA). Hepatology. vol. 23. pp. 1239-1243. (#116)



• Van Rooijen,N., 1996. Selective depletion of macrophages by liposome-encapsulated drugs. In: "Handbook of Experimental Immunology" 5e. Herzenberg,L., Herzenberg,L. & Weir,D., Eds. Blackwell Scientific Publications, Inc. USA.. pp. 165.1-165.5. (Chapter 165) . (#115)

1995:

• Vreden, S.G.S., Van den Broek, M.F., Oettinger, M.C., Boers, W., Van Rooijen, N., Meuwissen, J.H.E.T., & Sauerwein, R.W., 1995. Susceptibility to Plasmodium berghei infection in rats is modulated by the acute phase response. Parasite Immunol.. vol. 17. pp. 445-450. (#114)



• Vanderkerken,K., Bouwens,L., Van Rooijen,N., & Wisse,E., 1995. Role of Kupffer cells in the process of differentiation of pit cells in rat liver. In: "Cells of the Hepatic Sinusoid", Eds. E.Wisse, DL.Knook & K.Wake. Kupffer Cell Foundation, Leiden, The Netherlands.. vol. 5. pp. 145-147. (#113)



• Vanderkerken,K., Bouwens,L., Van Rooijen,N., Van den Berg,K., Baekeland,M., & Wisse,E., 1995. The role of Kupffer cells in the differentiation process of hepatic natural killer cells. Hepatology. vol. 22. pp. 283-290. (#112)



• Salkowski,C.A.,Neta,R.,Wynn,T.A.,Strassmann, G.,Van Rooijen,N. and Vogel,S.N., 1995. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J. Immunol.. vol. 155. pp. 3168-3179. (#111)



• Rocha,M., Kruger,A., Van Rooijen,N., Schirrmacher,V. & Umansky,V., 1995. Liver endothelial cells participate in T cell dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo. Int. J. Canc.. vol. 63. pp. 405-411. (#110)



• Fraser,C.C., Chen,B.P., Webb,S., Van Rooijen,N. & Kraal,G., 1995. Circulation of human hemopoietic cells in Severe Combined Immunodeficient mice following Cl2MDP-liposome mediated macrophage depletion. Blood. vol. 86. pp. 183-192. (#109)



• Tarazona, R., Gonzalez-Garcia,A., Zamzami,N., Marchetti,P., Frechin,N., Gonzalo,J.A., Ruiz-Gayo, M., Van Rooijen,N., Martinez-A,C. and Kroemer,G., 1995. Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. J. Immunol.. vol. 154. pp. 861-870. (#108)



• Van Lent,P.L.E.M., Holthuyzen,A.E.M.,Van Den Bersselaar,L.A.M.,Van Rooijen,N., Van De Putte,L.B.A. and Van Den Berg, W.B., 1995. Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. Scand. J. Rheumatol.(suppl. 101). vol. 24 . pp. 83-89. (#107)



• Schotanus, K., Holtkamp, G.M., Van Rooijen, N., Tilders, F.J.H. and Berkenbosch, F., 1995. Circulating tumor necrosis factor- a does not mediate endotoxin-induced hypothermia in rats. Am. J. Physiol.. vol. 268. pp. R989-R996. (#106)



• Marquet,R.L., Bonthuis,F., Duval, S.Y., DeBruin, R.W.F., Van Rooijen,N., Scheringa,M. and IJzermans J.N.M., 1995. Macrophages and nitric-oxide are involved in primary nonfunction of islet xenografts. Transpl. Proc.. vol. 27. pp. 252-253. (#105)



• Dai,R., Van Rooijen,N., Dijkstra,C.D., and Streilein,J.W., 1995. Relative roles of T cells and macrophages in cytokine-mediated functional transformation of cultured splenic dendritic cells. Cell. Immunol.. vol. 162. pp. 265-274. (#104)



• Huitinga,I., Ruuls,S.R., Jung,S., Van Rooijen,N., Hartung,H.-P. and Dijkstra,C.D., 1995. Macrophages in T cell line-mediated, demyelinating and chronic relapsing experimental autoimmu-ne encephalomyelitis in Lewis rats. Clin. Exp. Immunol.. vol. 100. pp. 344-351. (#103)



• Gaytan, F., Bellido, C., Morales, C., Van Rooijen, N. and Aguilar, E., 1995. Role of testicular macrophages in the response of Leydig cells to gonadotrophins in young hypophysectomized rats. J. Endocrinol.. vol. 147. pp. 463-471. (#102)



• Gaytan, F., Bellido, C., Morales, C., Reymundo, C., Aguilar, E. and Van Rooijen, N., 1995. Response to Leydig cell apoptosis in the absence of testicular macrophages. J. Reprod. Immunol.. vol. 29. pp. 81-94. (#101)



• Gaytan, F., Bellido, C., Aguilar, E. and Van Rooijen, N., 1995. Pituitary-testicular axis in rats lacking testicular macrophages. Eur. J. Endocrinol.. vol. 132. pp. 218-222. (#100)



• Buiting, A.M.J., De Rover, Z. And Van Rooijen, N., 1995. Brucella abortis causes an accellerated repopulation of the spleen and liver of mice by macrophages after their liposome-mediated depletion. J. Med. Microbiol.. vol. 42. pp. 133-140. (#99)



• Badell,E., Pasquetto,V.,Van Rooijen,N. and Druilhe,P., 1995. A mouse model for human malaria erythrocytic stages. Parasitology Today. vol. 11. pp. 235-237. (#98)



• Nair,S., Buiting, A.M.J., Van Rooijen,N., Huang,L. and Rouse,B.T., 1995. Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int.Immunol.. vol. 7. pp. 679-688. (#97)



• Bohm, W., Schirmbeck, R., Elbe, A., Melber, K., Diminsky, D., Kraal, G., Van Rooijen, N., Barenholz, Y. and Reimann, J., 1995. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. J. Immunol.. vol. 155. pp. 3313-3321. (#96)



• Biewenga,J., Van der Ende,.B., Krist,L.F.G., Borst,A., Ghufron,M. and Van Rooijen,N., 1995. Macrophage depletion and repopulation in the rat after ip.administration of Cl2MBP- liposomes: Depletion kinetics and accelerated repopulation of peritoneal and omental macrophages by administration of Freund's adjuvant.. Cell Tissue Res.. vol. 280. pp. 189-196. (#95)



• Van Rooijen,N., 1995. Liposome mediated immunopotentiation and immunomodulation. In: "Vaccines: New Generation Immunological Adjuvants". NATO ASI Series A: G.Gregoriadis, B.McCormack & A.C.Allison Eds. Plenum Press, New York, USA.. vol. 282. pp. 15-24. (#94)



• Van Rooijen,N., 1995. Functional aspects of macrophages: Studies using the liposome mediated macrophage "suicide" approach. In "Liposomes: New systems and new trends in their applications". (F.Puisieux, P.Couvreur, J.Delattre and J.P.Devissaguet, eds.) Editions de Sante, Paris. pp. 711-734 (Chapter 25). (#93)



• Van Rooijen,N., Bakker,J., Sanders,A. and Mellink, J., 1995. Killing of Entamoeba invadens using liposome-encapsulated drugs. Parasitol. Res.. vol. 81. pp. 258-261. (#92)

1994:

• Van Velthuysen, M-L.F., Mayen, A., Van Rooijen, N., Fleuren,G.J., De Heer, E. And Bruyn, J.A., 1994. T-cells and macrophages in the pathogenesis of infection-related glomerulopathy. Infect. Immun.. vol. 62. pp. 3230-3235. (#91)



• Marquet,R.L., Bouwman,E., Bonthuis,F., Kouwenhoven,E., Van Rooijen,N., Scheringa,M. and IJzermans J.N.M., 1994. Local immunological factors determine the occurrence of primary nonfunction of islet xenografts. Transpl. Proc.. vol. 26. pp. 766-767. (#90)



• Marquet, R.L., Bonthuis, F., Van Ijken, M., Bouwman, E., Wolvekamp. M.C.J., Van Rooijen,N.,Scheringa,M. and IJzermans J.N.M., 1994. Primary nonfunction of islet xenografts: The role of macrophages. Transplant.Int. (Suppl.1). vol. 7. pp. 660-662. (#89)



• Marquette,C., Van Dam,A-M., Van Rooijen,N., Berkenbosch,F. and Haour,F., 1994. Peripheral macrophage depletion prevents downregulation of central interleukin-1 receptors in mice after endotoxin administration. Psychoneuroendocrinol.. vol. 19. pp. 189-196. (#88)



• Kurimoto,I., Van Rooijen,N., Dijkstra,C.D. and Streilein,J.W., 1994. Role of phagocytic macrophages in induction of contact hypersensitivity and tolerance by hapten applied to normal and ultraviolet B-irradiated skin. Immunology. vol. 82. pp. 281-287. (#87)



• Gaytan, F., Bellido, C., Aguilar, E. and Van Rooijen,N., 1994. Requirement for testicular macrophages in Leydig cell proliferation and differentiation during prepubertal development in rats. J. Reprod. Fertil.. vol. 102. pp. 393-399. (#86)



• Gaytan, F., Bellido, C., Morales, C., Reymundo, C., Aguilar, E. and Van Rooijen,N., 1994. Effects of macrophage depletion at different times after treatment with ethylene dimethane sulphonate (EDS) on the regeneration of Leydig cells in the adult rat. J. Androl.. vol. 15. pp. 558-564. (#85)



• Gaytan,F.,Bellido,C.,Morales,C.,Reymundo,C.,Aguilar,E. and Van Rooijen, N., 1994. Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulfonate (EDS) in the rat. J. Reprod. Fertil.. vol. 101. pp. 175-182. (#84)



• Gonzalo, J.A., Baixeras, E., Gonzalez-Garcia, A., George-Chandy, A., Van Rooijen,N., Martinez, A.C. and Kroemer,G., 1994. Differential "in vivo" effects of a superantigen and an antibody targeted to the same T cell receptor. J. Immunol.. vol. 152. pp. 1597-1608. (#83)



• Qian, Q., Jutila, M.A., Van Rooijen, N. and Cutler, J.E., 1994. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J. Immunol.. vol. 152. pp. 5000-5008. (#82)



• Berra,A., Rodriguez,A., Heiligenhaus,A., Pazos,B., Van Rooijen,N. and Foster,C.S., 1994. The role of macrophages in the pathogenesis of HSV-1 induced chorioretinitis in Balb/c mice. Invest.Ophthalmol.. vol. 35. pp. 2990-2998. (#81)



• Van Der Veen,G.,Broersma,L.,Dijkstra,C.D.,Van Rooijen,N.,Van Rij,G.,Van Der Gaag,R., 1994. Prevention of corneal allograft rejection in rats treated with subconjunctival injections of liposomes containing dichloromethylene diphosphonate. Invest. Ophthalmol.. vol. 35. pp. 3505-3515. (#80)



• Litzinger,D.C.,Buiting,A.M.J.,Van Rooijen,N. and Huang,L., 1994. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic polyethylene-glycol containing liposomes. Bioch. Bioph. Acta. vol. 1190. pp. 99-107. (#79)



• Wijffels, J.F.A.M., De Rover, Z., Beelen, R.H.J., Kraal, G. and Van Rooijen, N., 1994. Macrophage subpopulations in the spleen renewed by local proliferation. Immunobiology. vol. 191. pp. 52-64. (#78)



• Van Lent,P.L.E.M., Holthuyzen,A.E.M.,Van Den Bersselaar,L.A.M.,Van Rooijen,N., Van De Putte,L.B.A. and Van Den Berg, W.B., 1994. Phagocytic synovial lining cells in propagation and exacerbation of smouldering synovitis. Agents and Actions. vol. 41. pp. C206-C208. (#77)



• Van Lent,P.L.E.M., Van Den Bersselaar,L.A.M.,Holthuyzen,A.E.M.,Van Rooijen,N., Van De Putte,L.B.A. and Van Den Berg, W.B., 1994. Phagocytic synovial lining cells in experimentally induced chronic arthritis: Downregulation of synovitis by Cl2MDP-liposomes. Rheumatol. Int.. vol. 13. pp. 221-228. (#76)



• De Rijk,R.H.,Van Kampen,M.,Van Rooijen,N. and Berkenbosch,F., 1994. Hypothermia to bacterial endotoxin in rats at sub-thermoneutral ambient temperatures involves reduced thermogenesis and macrophage-dependent mechanisms and is mediated by prostaglandins. Am. J. Physiol.. vol. 266. pp. R1-R8. (#75)



• Buiting, A.M.J. and Van Rooijen, N., 1994. Liposome mediated depletion of macrophages: An approach for fundamental studies. J. Drug Targeting. vol. 2. pp. 357-362. (#74)



• Van Rooijen,N., 1994. Liposome mediated modulation of macrophage functions. In "In Vivo Immunology: Regulatory Processes During Lymphopoiesis and Immunopoiesis". (Heinen,E. Ed.), Plenum Publish. Corp., New York. pp. 69-74. (#73)



• Van Rooijen, N., 1994. Liposomes in host defense mechanism: A key role for macrophages. J. Liposome Research. vol. 4. pp. 193-201. (#72)



• Van Rooijen,N. and Sanders,A., 1994. Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications. J. Immunol. Meth.. vol. 174. pp. 83-93. (#71)

1993:

• Van den Dobbelsteen,G.P.J.M.,Brunekreef,K.,Kroes,H.,Van Rooijen,N. and Van Rees,E.P., 1993. Enhanced triggering of mucosal immune responses by reducing splenic phagocytic functions. Eur. J. Immunol.. vol. 23. pp. 1488-1493. (#70)



• Nieuwenhuijzen, G.A.P., Haskel, Y., Lu, Q., Berg, R.D., Van Rooijen, N.,Goris,R.J.A. and Deitch,E.A., 1993. Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symtoms and mortality rate in a model of systemic inflammation. Annals Surg.. vol. 218. pp. 791-799. (#69)



• De Rijk,R.H., Strijbos,P.J.L.M.,Van Rooijen,N.,Rothwell,N.J.and Berkenbosch,F., 1993. Fever and thermogenesis in response to bacterial endotoxin (LPS) involves macrophage-dependent mechanisms in the rat. Am. J. Physiol.. vol. 265. pp. R1179-R1183. (#68)



• Curfs,J.H.A.J., Hermsen,C.C., Meuwissen,J.H.E.Th., Van Rooijen,N. and Eling W.M.C., 1993. Tumor necrosis factor-a and monocytes in Plasmodium Berghei-induced cerebral malaria. Parasitology. vol. 107. pp. 125-134. (#67)



• Van Lent, P.L.E.M.,Van De Hoek,A.,Van Den Bersselaar,L.,Van Rooijen,N. and Van Den Berg, W.B., 1993. Role of phagocytic synovial lining cells in experimental arthritis. Agents and Actions. vol. 38. pp. C92-C94. (#66)