Publications

2003:

• Yi, S., Hawthorne, W.J., Lehnert, A.M., Ha, H., Kwok Wah Wong, J., Van Rooijen, N., Davey, K., Patel, A.T., Walters, S.N., Chandra, A., O’Connell, P.J. , 2003. T cell activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J. Immunol. . vol. 170. pp. 2750-2758. (#267)



• Slegers, T., Van der Gaag, R., Van Rooijen, N., Van Rij, G., Streilein, W. , 2003. Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts. Curr. Eye Res. . vol. 26. pp. 73-79. (#266)



• Alves-Rosa, F., Vermeulen, M., Cabrera, J., Stanganelli, C., Capozzo, A., Narbaitz, M., Van Rooijen, N., Palermo, M., Isturiz, M.A. , 2003. Macrophage depletion following liposomal encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice.. Brit. J. Haematol. . vol. 121. pp. 130-138. (#265)



• Wu, G., Korsgren, O., Sun, S., Van Rooijen, N., Tibell, A. , 2003. Effect of plasma exchange in combination with deoxyspergualin on the survival of guinea pig hearts in macrophage-depleted C6-deficient rats.. Xenotransplantation. vol. 10. pp. 214-222. (#263)



• Knapp, S., Leemans, J.C., Florquin, S., Branger, J., Maris, N.A., Pater, J.M., Van Rooijen, N., Van Der Poll, T. , 2003. Alveolar macrophages have a protective anti-inflammatory role during murine pneumococcal pneumonia.. Am. J. Respir. Crit. Care Med. . vol. 167. pp. 171-179. (#262)



• Dickson, B.C., Yang, H., Savelkoul, H.F.J., Rowden, G., Van Rooijen, N., Wright Jr, J.R , 2003. Islet transplantation in the discordant tilapia-to-mouse model: A novel application of alginate microencapsulation in the study of xenograft rejection.. Transplantation. vol. 75. pp. 599-606. (#261)



• Chuah, M.K.L., Schiedner, G., Thorrez, L., Brown, B., Johnston, M., Gillijns, V., Hertel, S., Van Rooijen, N., Lillicrap, D., Collen, D., VandenDriessche, T., Kochanek, S., 2003. Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.. Blood. vol. 101. pp. 1734-1743. (#260)



• Omer, A., Keegan, M., Czismadia, E., De Vos, P., Van Rooijen, N., Bonner-Weir, S., Weir, G.C. , 2003. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. vol. 10. pp. 240-251. (#255)



• Jordan, M.B., Van Rooijen, N., Izui, S., Kappler, J., Marrack, P., 2003. Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model. Blood. vol. 101. pp. 594-601. (#244)

2002:

• Sedger, L.M., Hou, S.M., Osvath, S.R., Glaccum,M.B., Peschon, J.J., Van Rooijen, N., Hyland, L., 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.. J. Immunol.. vol. 169. pp. 6193-6201. (#264)



• Belnoue, E., Kayibanda, M., Vigario, A.M., Deschemin, J-C., Van Rooijen, N., Viguier, M., Snounou, G., Renia, L. , 2002. On the pathogenic role of brain-sequestered alpha-beta CD8+ T cells in experimental cerebral malaria.. J. Immunol.. vol. 169. pp. 6369-6375. (#259)



• Wijburg, O.L.C., Van Rooijen, N., Strugnell, R.A. , 2002. Induction of CD8+ T lymphocytes by Salmonella typhimurium is independent of Salmonella pathogenicity island 1-mediated host cell death.. J. Immunol.. vol. 169. pp. 3275-3283. (#258)



• Gregory, S.H., Cousens, L.P., Van Rooijen, N., Dopp, E.A., Carlos, T.M., Wing, E.J. , 2002. Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J. Immunol.. vol. 168. pp. 308-315. (#257)



• Guo, R.F., Lentsch, A.B., Vidya Sarma, J., Sun, L., Riedemann, N.C., McClintock, S.D., McGuire, S.R., Van Rooijen, N., Ward, P.A. , 2002. Activator protein-1 activation in acute lung injury. Am. J. Pathol.. vol. 161. pp. 275-282. (#256)



• Knudsen, E., Iversen, P.O., Van Rooijen, N., Benestad, H.B. , 2002. Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat. Eur. J. Haematol.. vol. 69. pp. 284-296. (#254)



• Djeraba, A., Musset, E., Van Rooijen, N., Quere, P. , 2002. Resistance and susceptibility to Marek’s disease: nitric oxide synthase/arginase activity balance. Vet. Microbiol.. vol. 86. pp. 229-244. (#253)



• Kolaczkowska, E., Shahzidi S., Seljelid. R., Van Rooijen, N., Plytycz, B., 2002. Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: Crucial involvement of macrophage-derived cysteinyl-leukotrienes. Inflammation. vol. 26. pp. 61-71. (#252)



• Kielian, T., Van Rooijen, N., Hickey, W.F. , 2002. MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo. J. Neuro-Oncology. vol. 56. pp. 1-12. (#251)



• Polfliet, M.M.J., Van de Veerdonk, F., Dopp, E.A., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K. , 2002. Perivascular and meningeal macrophages play a role during the onset of experimental allergic encephalomyelitis. J. Neuroimmunol.. vol. 122. pp. 1-8. (#250)



• Marshall, J., McEachern, K., Kyros, J., Nietupski, J., Budzinski, T., Ziegler, R., Yew, N., Sullivan, J., Scaria, A., Van Rooijen, N., Barranger, J., Cheng, S. , 2002. Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model. Mol. Ther.. vol. 6. pp. 179-189. (#249)



• Ziegler, R.J., Li, C., Cherry, M., Zhu, Y., Hempel, D., Van Rooijen, N., Ioannou, Y.A., Desnick, R.J., Goldberg, M.A., Yew, N.S., Cheng, S.H. , 2002. Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. . Human Gene Therapy. vol. 13. pp. 935-945.. (#248)



• Bauer, D., Schmitz, A., Van Rooijen, N., Steuhl, K-P., Heiligenhaus, A, 2002. Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus 1 infection. Immunology. vol. 107. pp. 118-128. (#246)



• Haeberle,H.E., Takizawa, R., Casola, A., Brasier, A.R., Dieterich, H.J., Van Rooijen, N., Gatalica, Z., Garofalo, R.P, 2002. Respiratory syncytial virus-induced activation of Nuclear Factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4 - dependent pathways.. J. Infect. Dis. vol. 186. pp. 1199-1206. (#245)



• Alves-Rosa, F., Stanganelli, C., Cabrera, J.,Cymberknop, D., Rubel, C., Vanzulli, S., Van Rooijen, N., Palermo, M., Isturiz, M.A, 2002. Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia.. Brit. J. Haematol.. vol. 116. pp. 357-366. (#243)



• Van Rooijen N., Van Kesteren-Hendrikx, E., 2002. Clodronate liposomes: perspectives in research and therapeutics. J. Liposome Research. vol. 12. pp. 81-94. (#242)

2001:

• Wu, G.S., Korsgren, O., Van Rooijen, N., Tibell, A., 2001. Suppression of T cells results in long-term survival of mouse heart xenografts in C6-deficient rats. Xenotransplantation. vol. 8. pp. 303-309. (#247)



• Laverman, P., Carstens, M.G., Boerman, O.C., Dams, E.Th.M., Oyen, W.J.G., Van Rooijen, N., Corstens, F.H.M., Storm, G., 2001. Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection. J. Pharm. Exp. Ther.. vol. 298. pp. 607-612. (#239)



• Moreno, A., Badell, E., Van Rooijen, N., Druilhe, P., 2001. Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies. Antimicrob. Agents. Chemother.. vol. 45. pp. 1847-1853. (#238)



• Teeling, J.L., Bleeker, W.K., Rigter, G.M.M., Van Rooijen, N., Kuijpers, T.W., Hack, C.E., 2001. Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages - studies in a rat model. Brit. J. Haematol.. vol. 112. pp. 1031-1040. (#237)



• Kotter, M.R., Setzu, A., Sim, F.J.,Van Rooijen, N., Franklin, R.J.M., 2001. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia. vol. 35. pp. 204-212. (#236)



• Hayley, S., Lacosta, S., Merali, Z., Van Rooijen, N., Anisman, H., 2001. Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects. Eur. J. Neurosci.. vol. 13. pp. 1155-1165. (#235)



• Polfliet, M.M.J., Goede, P.H., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K., 2001. A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system. J. Neuroimmunol.. vol. 116. pp. 188-195. (#234)



• Zito, M.A., Koennecke, L.A., McAuliffe, M.J., McNally, B., Van Rooijen, N., Heyes, M.P., 2001. Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates striatal macrophage invasion and neurodegeneration following local endotoxin infusion in gerbils. Brain Res.. vol. 892. pp. 13-26. (#233)



• Everse, L.A., Anderson, L.D., Van Rooijen, N., Mullen, C.A., 2001. Bone marrow transplant conditioning intensified with liposomal clodronate to eliminate residual host antigen presenting cells fails to ameliorate GVHD and increases PERI-BMT mortality. Transplantation. vol. 71. pp. 611-618. (#232)



• Polfliet, M.M.J., Zwijnenburg, P.J.G., Van Furth, A.M., Van Der Poll, T., Dopp, E.A., Renardel De Lavalette, C., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K., 2001. Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. J. Immunol.. vol. 167. pp. 4644-4650. (#231)



• Salez, L., Balloy, V., Van Rooijen, N., Lebastard, M., Touqui, L., McCormack, F.X., Chignard, M., 2001. Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages. J. Immunol.. vol. 166. pp. 6376-6382. (#230)



• Guillot, C., Coathalem, H., Chetritt, J., David, A., Lowenstein, P., Gilbert, E., Tesson, L., Van Rooijen N., Cuturi, M.C., Soulillou, J.P., Anegon, I., 2001. Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4 induced hepatitis. J. Immunol.. vol. 166. pp. 5225-5235. (#229)



• Leemans, J.C., Juffermans, N.P., Florquin, S., Van Rooijen, N., Vervoordeldonk, M.J., Verbon, A., Van Deventer, S.J.H., Van der Poll, T., 2001. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol.. vol. 166. pp. 4604-4611. (#228)



• Tang, C., Inman, M.D., Van Rooijen, N., Yang, P., Shen, H., Matsumoto, K., O'Byrne, P.M., 2001. Th type 1-stimulating activity of lung macrophages inhibits Th 2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism. J. Immunol.. vol. 166. pp. 1471-1481. (#227)



• Bauer, D., Mrzyk, S., Van Rooijen, N., Steuhl, K.P, Heiligenhaus, A., 2001. Incidence and severity of herpetic stromal keratitis: Impaired by the depletion of lymph node macrophages. Exp. Eye Res.. vol. 72. pp. 261-269. (#226)



• Lehner, M.D., Ittner, J., Bundschuh, D.S., Van Rooijen, N., Wendel, A., Hartung, T., 2001. Improved innate immunity. of endotoxin-tolerant mice increases resistance to Salmonella enterica Serovar Typhimurium infection despite attenuated cytokine response.. Infect. Immun.. vol. 69. pp. 463-471. (#225)

2000:

• Honing, H., Van Rooijen, N., Van Den Berg, T.K., 2000. Manipulation of macrophage activities using liposomes. J. Liposome Research. vol. 10. pp. 359-389. (#224)



• Rutkowski, M.D., Pahl, J.L., Sweitzer, S., Van Rooijen, N., DeLeo, J.A., 2000. Limited role of macrophages in the generation of nerve injury-induced mechanical allodynia. Physiol. Behavior.. vol. 71. pp. 225-235. (#223)



• Zhang-Hoover, J., Sutton, A., Van Rooijen, N., Stein-Streilein, J., 2000. A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis. Immunology. vol. 101. pp. 501-511. (#222)



• Ciavarra, R.P., Greene, A.R., Horeth, D.R., Buhrer, K., Van Rooijen, N., Tedeschi, B., 2000. Antigen processing of vesicular stomatitis virus in situInterdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4+ and CD8+ T cells.. Immunology. vol. 101. pp. 512-520. (#221)



• Emoto, M., Miyamoto, M., Namba, K., Schmits, R., Van Rooijen, N., Kita, E., Kaufmann, S.H.E., 2000. Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver. Eur. J. Immunol.. vol. 30. pp. 3049-3056. (#220)



• Badell, E., Oeuvray, C., Moreno, A., Soe, S., Van Rooijen, N., Bouzidi, A., Druilhe, P., 2000. Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium Falciparum.. J. Exp. Med.. vol. 192. pp. 1653-1659. (#219)



• Sekine Y., Yasufuku, K., Heidler, K.M., Cummings, O.W., Van Rooijen, N., Fujisawa, T, Brown, J., Wilkes, D.S., 2000. Monocyte Chemoattractant Protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. Am. J. Respir. Cell Mol. Biol.. vol. 23. pp. 719-726. (#218)



• Schumann, J., Wolf, D., Pahl, A., Brune, K., Papadopoulos, T., Van Rooijen, N., Tiegs, G., 2000. Importance of Kupffer cells for T cell-dependent liver injury in mice. Am. J. Pathol.. vol. 157. pp. 1671-1683. (#217)



• Miyamoto, M., Emoto, M., Brinkmann, V., Van Rooijen, N., Schmits, R., Kita, E., Kaufmann, S.H.E., 2000. Contribution of NK cells to the homing of thymic CD4+NKT cells to the liver. J. Immunol.. vol. 165. pp. 1729-1732. (#216)



• Alves-Rosa, F., Stanganelli, C., Cabrera, J., Van Rooijen, N., Palermo, M.S., Isturiz, M.A., 2000. Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune. thrombocytopenic purpura in a mouse model.. Blood. vol. 96. pp. 2834-2840. (#215)



• Van Overdam, K.A., Verbakel. C.A.E., Kouwenhoven, E.A., Van Rooijen, N., De Bruin, R.W.F., Ijzermans, J.N.M., Marquet, R.L., 2000. Negligible role for NK cells and macrophages in delayed xenograft rejection. Transplant. Int.. vol. 13, (Suppl.1). pp. S504-S507. (#214)



• Wu, G., Korsgren, O., Zhang, J., Song, Z., Van Rooijen, N., Tibell, A., 2000. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation. vol. 7. pp. 214-220. (#213)



• Barrera, P., Blom, A., Van Lent, P.L.E.M., Van Bloois, L., Storm, G., Beijnen, J., Van Rooijen, N., Van De Putte, L.B.A., Van Den Berg, W.B., 2000. Synovial macrophage depletion with clodronate containing liposomes in rheumatoid arthritis. Arthritis Rheum.. vol. 43. pp. 1951-1959. (#212)



• Cheng, H., Tumpey, T.M., Staats, H.F., Van Rooijen, N., Oakes, J.E., Lausch, R.N., 2000. Role of macrophages in restricting Herpes Simplex Virus Type 1 growth after ocular infection. Invest. Ophthalmol. Vis. Res.. vol. 41. pp. 1402-1409. (#211)



• Van der Hoek, K.H., Maddocks, S., Woodhouse,C.M., Van Rooijen, N., Robertson, S.A., Norman, R.J., 2000. Intrabursal injection of clodronate liposomes causes macrophage depletion and inhibits ovulation in the mouse ovary. Biol. Reproduct.. vol. 62. pp. 1059-1066. (#210)



• Slegers, T.P.A.M., Torres, P.F., Broersma, L., Van Rooijen, N., Van Rij, G., Van der Gaag, R., 2000. Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats. Invest. Ophthalmol. Vis. Res.. vol. 41. pp. 2239-2247. (#209)



• Slegers, T.P.A.M., Van Rooijen, N., Van Rij, G., Van der Gaag, R., 2000. Delayed corneal graft rejection in high-risk eyes after subconjunctival injection of clodronate liposomes. Curr. Eye Res.. vol. 20. pp. 322-324. (#208)



• Meijer, C., Wiezer, M.J., Diehl, A.M., Yang, S-Q., Schouten, H.J., Meijer, S., Van Rooijen, N., Van Lambalgen, A.A., Dijkstra, C.D., Van Leeuwen, P.A.M., 2000. Kupffer cell depletion by Cl2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. Liver. vol. 20. pp. 66-77. (#207)



• Wijburg. O.L.C., Simmons, C.P., Van Rooijen, N. Strugnell, R.A., 2000. Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. typhimurium infections in mice.. Eur. J. Immunol.. vol. 30. pp. 944-953. (#206)



• Westerhuis, R., Van Straaten, S.C., Van Dixhoorn, M.G.A., Van Rooijen, N., Verhagen, N.A.M., Dijkstra, C.D., De Heer, E., Daha, M.R., 2000. Distinctive roles of neutrophils and monocytes in anti-Thy-1 nephritis. Am. J. Pathol.. vol. 156. pp. 303-310. (#205)



• Vajdova,K., Smrekova, R., Kukan, M., Jakubovsky, J., Van Rooijen, N., Horecky, J., Lutterova, M., Wsolova, L., 2000. Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. J. Hepatol.. vol. 32. pp. 112-120. (#204)



• Galeazzi, F., Haapala, E.M., Van Rooijen, N., Vallance, B.A., Collins, S.M., 2000. Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am. J. Physiol.. vol. 278. pp. G259-G265. (#203)



• Liu, T., Van Rooijen, N., Tracey, D.J., 2000. Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. Pain. vol. 86. pp. 25-32. (#202)



• Laverman, P., Brouwers, A.H., Oyen, W.J.G., Dams, E.Th.M., Van Rooijen, N., Corstens, F.H.M., Storm, G., Boerman, O.C., 2000. Dose effect of stealth-liposomes; disappearance of long-circulating characteristics at low lipid dose. J. Pharm. Exp. Ther.. vol. 293. pp. 996-1001. (#201)



• Bauer, D., Mrzyk, S., Van Rooijen, N., Steuhl, K.P., Heiligenhaus, A., 2000. Macrophage-depletion influences the course of murine HSV-1 keratitis. Curr. Eye Res.. vol. 20. pp. 45-53. (#200)



• Van Rooijen, N., Van Kesteren-Hendrikx, E., 2000. Analysis of macrophage activity in vivo. In: "Macrophages: A practical approach". Ed: D.M. Paulnock, Oxford University Press, Oxford, UK.. pp. 157-172. (#199)

1999:

• Wijburg, O.L.C., Strugnell, R.A. and Van Rooijen, N., 1999. Macrophages in viral immunity. Regulation of acquired immune responses.. Current Topics in Virology. vol. 1. pp. 127-138. (#240)



• Trostdorf, F., Bruck, W., Schmitz-Salue, M., Stuertz, K., Hopkins, S.J., Van Rooijen, N., Huitinga, I., Nau, R., 1999. Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis. J. Neuroimmunol.. vol. 99. pp. 205-210. (#198)



• Torres, P.F., Slegers, T.P.A.M., Peek, R., Van Rooijen, N., Van der Gaag, R., Kijlstra, A., De Vos, A.F., 1999. Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment. Invest. Ophthalmol.. vol. 40. pp. 3194-3201. (#197)



• Koennecke, L.A., Zito, M.A., Proescholdt, M.G., Van Rooijen, N., Heyes, M.P., 1999. Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates increases in brain quilonic acid during CNS-localized and systemic immune activation. J. Neurochem.. vol. 73. pp. 770-779. (#196)



• Wu, G., Korsgren, O., Van Rooijen, N., Wennberg, L., Tibell, A., 1999. The effect of macrophage depletion on delayed xenograft rejection: Studies in the guinea pig to C6-deficient rat heart transplantation model. Xenotransplantation. vol. 6. pp. 262-270. (#195)



• Lentsch, A.B., Czermak, B.J., Bless, N.B., Van Rooijen, N., Ward, P.A., 1999. Essential role of alveolar macrophages in intrapulmonary activation of NF-kB. Am. J. Respir. Cell Mol. Biol.. vol. 20. pp. 692-698. (#194)



• Popovich, P.G., Guan, Z., Wei, P., Huitinga, I., Van Rooijen, N., Stokes, B.T., 1999. Depletion of hematogenous macrophages promotes partial neurologic recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol.. vol. 158. pp. 351-365. (#193)



• Palermo, M.S., Alves Rosa, M.F., Van Rooijen, N., Isturiz, M.A., 1999. Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model. Clin. Exp. Immunol.. vol. 116. pp. 462-467. (#192)



• Kradin, R.L., Liu, H.W., Van Rooijen, N., Springer, K., Zhao, L.H., Leary, C.P., 1999. Pulmonary immunity to Listeria is enhanced by elimination of alveolar macrophages. Am. J. Respir. Crit. Care Med.. vol. 159. pp. 1967-1974. (#191)



• Kopydlowski, K.M., Salkowski, C.A., Cody, M.J., Van Rooijen, N., Major, J., Hamilton, T.A., Vogel, S.N., 1999. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J. Immunol.. vol. 163. pp. 1537-1544. (#190)



• Kodukula, P., Liu, T., Van Rooijen, N., Jager, M.J., and Hendricks, R.L., 1999. Macrophage control of Herpes Simplex Virus Type 1 replication in the peripheral nervous system. J. Immunol.. vol. 162. pp. 2895-2905. (#189)



• Jun, H.S., Yoon, C.S., Zbytnuik, L., Van Rooijen, N., and Yoon, J.W., 1999. The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Exp. Med.. vol. 189. pp. 347-358. (#188)



• Jiang, Q., DeTolla, L., Singh, I.S., Gatdula, L., Fitzgerald, B., Van Rooijen, N., Cross, A,S., and Hasday, J.D., 1999. Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. Am. J. Physiol.. vol. 276. pp. 1653-1660. (#187)



• Jiang, Q., DeTolla, L., Van Rooijen, N., Singh, I.S., Fitzgerald, B., Lipsky, M.M., Kane, A.S., Cross, A,S., and Hasday, J.D., 1999. Febrile-range temperature modifies early systemic TNFa expression in mice challenged with bacterial endotoxin. Infect. Immun.. vol. 67. pp. 1539-1546. (#186)



• Xue, S., Sun, N., Van Rooijen, N., Perlman, S., 1999. Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus. J. Virol.. vol. 73. pp. 6327-6334. (#185)



• Hoch, J.R., Stark, V.K., Van Rooijen, N., Kim, J.l., Nutt, M.P., Warner, T.F., 1999. Macrophage depletion alters vein graft intimal hyperplasia. Surgery. vol. 126. pp. 428-437. (#184)



• Hanson, L.K., Slater, J.S., Karabekian, Z., Virgin, H.W., Biron, C.A., Ruzek, M.C., Van Rooijen, N., Ciavarra, R.P., Stenberg, R.M., Campbell, A.E., 1999. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis. J. Virol.. vol. 73. pp. 5970-5980. (#183)



• Schughart, K., Bischoff, R., Ali Hadji, D., Boussif, O., Perraud, F., Accart, N., Rasmussen, U.B., Pavirani, A., Van Rooijen, N. and Kolbe, H.V.J., 1999. Effect of liposome-encapsulated clodronate pretreatment on synthetic vector-mediated gene expression in mice. Gene Therapy. vol. 6. pp. 448-453. (#182)

1998:

• Mielcarek, N., Nordstrom, I., Van Rooijen, N., Menozzi, F.D., Locht, C. and Holmgren, J., 1998. Effect of alveolar macrophage depletion during Bordetella pertussis infection in C57bl/6 mice: decreased bacterial clearance and modified immune responses. Proc. 10th Int. Congr. Immunology (G.P.Talwar, I.Nath, N.K.Ganguly, K.V.S.Rao, eds.), New Delhi. pp. 1023-1027. (#180)



• Dunstan, S.J., Simmons, C.P., Wijburg, O.L.C., Uren, T.K., Van Rooijen, N., and Strugnell, R.A., 1998. Studies of the pathogenesis and immunology of attenuated mutants of Salmonella enterica var. Typhimurium: lessons for human typhoid fever?. Med. J. Indonesia. vol. vol.7 (suppl.1). pp. 74-80. (#179)



• Fox, A., Koulmanda,M., Mandel, T.E., Van Rooijen, N., Harrison, L.C., 1998. Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation. vol. 66. pp. 1407-1416. (#178)



• Van Der Veen, G., Broersma, L., Van Rooijen, N., Van Rij, G. and Van Der Gaag, R., 1998. Cytotoxic T lymphocytes and antibodies after orthotropic penetrating keratoplasty in rats treated with dichloromethylene diphosphonate encapsulated liposomes. Curr. Eye Res.. vol. 17. pp. 1018-1026. (#177)



• Tran, E.H., Hoekstra, K., Van Rooijen, N., Dijkstra, C.D. and Owens, T., 1998. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol.. vol. 161. pp. 3767-3775. (#176)



• Pouvreau, I., Zech, J-C., Thillaye-Goldenberg, B., Naud, M.C., Van Rooijen, N., De Kozak, Y., 1998. Effect of macrophage depletion by liposomes containing dichloromethylene diphosphonate on endotoxin-induced uveitis. J. Neuroimmunol.. vol. 86. pp. 171-181. (#175)



• Stein, C.S., Pemberton, J.L., Van Rooijen, N. and Davidson, B.L., 1998. Effects of macrophage depletion and anti-CD40L ligand on transgene expression and redosing with recombinant adenovirus. Gene Therapy. vol. 5. pp. 431-439. (#174)



• Oussoren, C., Velinova, M., Scherphof, G., Van der Want, J.J., Van Rooijen, N., Storm, G., 1998. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection IV. Fate of liposomes in regional lymph nodes.. Bioch. Bioph. Acta. vol. 1370. pp. 259-272. (#173)



• Bakker, J., Sanders, A., Van Rooijen, N., 1998. Effects of liposome-encapsulated drugs on macrophages: comparative activity of the diamidine 4',6-diamidino-2-phenylindole and the phenanthridinium salts ethidium bromide and propidium iodide. Bioch. Bioph. Acta. vol. 1373. pp. 93-100. (#172)



• Jeurissen, S.H.M., Janse, E.M., Van Rooijen, N., Claassen, E., 1998. Inadequate anti-polysaccharide antibody responses in the chicken. Immunobiology. vol. 198. pp. 385-395. (#171)



• Claassen, I.J.T.M., Osterhaus, A.D.M.E., Poelen, M., Van Rooijen, N., Claassen, E., 1998. Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen, II Cellular, but not humoral, systemic immune responses against rabies virus immune-stimulating complexes are macrophage dependent.. Immunology. vol. 94. pp. 455-460. (#170)



• Leenen, P.J.M., Radosevic, K., Voerman, J.S.A., Salomon, B., Van Rooijen, N., Klatzmann, D. and Van Ewijk, W., 1998. Heterogeneity of mouse spleen dendritic cells: In vivo phagocytic activity, expression of macrophage markers and subpopulation turnover. J. Immunol.. vol. 160. pp. 2166-2173. (#169)



• Gregory, S.H., Wing, E.J., Danowski, K.L., Van Rooijen, N., Dyer, K.F. and Tweardy, D.J., 1998. IL-6 Produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic Listerial infections. J. Immunol.. vol. 160. pp. 6056-6061. (#168)



• Van Lent, P.L.E.M., Holthuyzen, A.E.M., Van Rooijen, N., Van De Putte, L.B.A. and Van Den Berg, W.B., 1998. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann. Rheum. Dis.. vol. 57. pp. 408-413. (#167)



• Van Lent, P.L.E.M., Holthuyzen, A.E.M., Van Rooijen, N., Van De Loo, F.A.J., Van De Putte, L.B.A. and Van Den Berg, W.B., 1998. Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis. J. Rheumatol.. vol. 25. pp. 1135-1145. (#166)