Current Projects

• Macrophage and host response to nematode infection 
  Submitted by Aiping Zhao  (University of Maryland School of Medicine, Baltimore, Maryland, United States) 8/26/2010
  The project is to investigate the role of macrophage and the associated cytokines in the regulation of host immune response against nematode infection.



• Evaluate the role of monocytes/macrophages versus other cells in the development of CHS reaction 
  Submitted by Marc VOCANSON  (INSERM U851, Lyon, France) 8/25/2010
  Hapten paintin gonto the skin prompts the recruitment of numerous inflammatory cells. Recently, it has been reported that monoyte/macrophage populations recruited upon hapten painting dramatically impact the developpment and the magnitude of CHS reaction. Here, we intended to explore the role of other inflammatory cells versus monocytes/macrophages recruited upon hapten painting.
  More: http://www.ifr128.prd.fr/ifr128.htm



• Depletion of AT macrophages 
  Submitted by Christina Camell  (Baylor College of Medicine, Houston, Tx, United States) 8/23/2010
  The aim is to test the role of the AT macrophages in initiating an inflammatory response followig a high fat diet



• Role of Kupffer cells in hepatic fibrosis 
  Submitted by Stefan Wirtz  (University of Erlangen-Nuremberg, Erlangen, Germany) 8/23/2010
  We are working with mouse models of hepatic fibrosis. We would like to deplete Kupffer cells to study their role in cytokine induced processes leading to tissue remodelling in the liver.



• Stromal cell-driven emergency myelopoiesis 
  Submitted by Steffen Boettcher  (Hematology, University Hospital Zurich, Zurich, Switzerland) 8/20/2010
  We seek to determine the relative contribution of non-hematopoietic bone marrow stromal cells to emergency myelopoietic responses.



• Macrophages and pneumococcal infections 
  Submitted by Birgitta Henriques Normark  (Karolinska Institutet and Smittskyddsinstitutet, Stockholm, Sweden) 8/19/2010
  We would like to do in vivo infections with wild type and mutant pneumococci where we have depleted the macrophages
  More: http://www.ki.se



• Immunomodulation of tumor rejection in a mouse model of melanoma. 
  Submitted by Bhaskar Srivastava  (Yale Immunobiology Department, New Haven, CT, United States) 8/18/2010
  We are working with a mouse model of melanoma generated by Marcus Bosenberg and colleagues (Dankort et al., Nature Genetics 2009) in which simulataneous inducible activation of BRAF and deletion of PTEN on the skin leads to growth of melanoma. We are interested in modulating the immune response to cause rejection or delayed growth of the tumor, and would like to delete macrophages (splenic and within the tumor) using your clodronate liposomes.



• regenerative medicine 
  Submitted by Shinichi Fukuda  (Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan, Tsukuba city, Ibaraki prefecture, Japan) 8/18/2010
  Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Also investigate the relationship between endothelial progenitor cells and macrophages.



• Liver-Lung signalling during chronic ethanol ingestion 
  Submitted by Kyle Happel  (LSU Health Sciences Center, New Orleans, LA, United States) 8/17/2010
  We are interested in the role of the gut and liver in the pathogenesis of ethanol-induced lung injury.



• Role of macrophage in allogeneic stem cell transplantation 
  Submitted by Satoshi Nishwiaki  (Nagoya University Graduate School of Medicine, Department of Hematology and Oncology, Nagoya, Japan) 8/17/2010
  We aim at examining the role of marophage in allogeneic stem cell transplantation. To deplete macrophages, we want to administer chlodronate liposome.