Current Projects

This is a list of projects currently using Clodronate Liposomes.
To submit your own project to this list, click here.
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Once results of a project are published, the project is moved to Publications.

• Reduction in alveolar macrophages mitigates organ injury and systemic inflammation in ventilator-induced lung injury rats 
  Submitted by tutu hoo  (Department of Anesthesiology in Guangzhou First Municipal People`s Hospital, Guangzhou City, Guangdong Province, 510180, China., China) 7/31/2010
  The aim of the project is to study the role of macrophages in nonpulmonary organ dysfunction, which is induced by high tidal volume mechanical ventilation. High tidal volume ventilation induces cardiovascular, pulmonary, and liver injury as well as a systemic proinflammatory response. Alveolar macrophages have been known to play a vital role in local and systemic inflammatory cascade activation when the lung is exposed to noxious stimuli.
  More: http://space.feixin.10086.cn/12713072/blog



• The role of Kupfer cells in obesity 
  Submitted by Beata Mierzejewska  (University of Toledo, Toledo Ohio , United States) 7/30/2010
  The project is designed to test hypothesis that Kupfer cells are important in high fat diet induced obesity



• The role of Kupfer cells in obesity 
  Submitted by Beata Mierzejewska  (University of Toledo, Toledo Ohio , United States) 7/30/2010
  This project will examine whether long term blockade of Kupfer cells may accelerate the process of high fat diet induced obesity.



• Macrophage mobilization after myocardial infarction 
  Submitted by Victor Dayan  (Princess Margaret Hospital, Toronto, Ontario, Canada) 7/28/2010
  Study cardiac function after MI with and without macrophage depletion.



• Relationship between adipose tissue depot dependent macrophage infiltration and insulin resistance 
  Submitted by Injae Hwang  (Seoul National University, Seoul, Korea, South) 7/27/2010
  Fat tissue inflammation is associated with immune cell infiltration such as macrophage and T-cell which is originated by obesity and metabolic syndrome which is deeply correlated with insulin resistance. But fat-depot specific characterization of inflammation has not been fully elucidated.
  More: http://plaza.snu.ac.kr/jbkim



• Role of Lung Macrophage in chronic asthma remodeling 
  Submitted by Alex Pham  (UCSD, La Jolla, CA, United States) 7/26/2010
  We are interested in studying the role of lung macrophage in chronic asthma airway remodeling



• Peripheral Macrophage Depletion 
  Submitted by Markus Sigrist  (University of Basel, Basel, Switzerland) 7/26/2010
  Deplete macrophages in periphery by injection of liposomes



• Role of alternatively activated macrophages in helminth infection 
  Submitted by Colby Zaph  (University of British Columbia, Vancouver, BC, Canada) 7/23/2010
  Alternatively activated macrophages are associated with Th2 cell responses and control of helminth infection. Mice deficient in the lipid phosphatase SHIP spontaneously develop AAMacs. Surprisingly, SHIP KO mice are susceptible to infection with the parasitic helminth Trichuris. To test whether AAMacs are responsible for this susceptibility, macrophages will be deleted using clodronate liposomes.
  More: http://www.brc.ubc.ca/drupal5/czaph



• Development of insulin resistance in mice during pregnancy 
  Submitted by Nitsa Mirsky  (Albert Einstein College of Medicine, Bronx, NY 10461, United States) 7/23/2010
  We found an increase of insulin resistance in mice during pregnancy. We would like to explore the involvement of the immune system in general, and macrophages in particular, in this process. We plan to reduce the immune response in female mice in the beginning of their pregnancy, and to follow their glucose tolerance test in parallel to untreated pregnant mice.



• Role of macrophages in acute kidney injury 
  Submitted by Meghan Clements  (Genzyme, Framingham, MA, United States) 7/22/2010
  Liposome clodronate will be used to deplete macrophages in the different stanges of acute kidney injury including: initial injury, recovery and long term fibrosis.