Current Projects

This is a list of projects currently using Clodronate Liposomes.
To submit your own project to this list, click here.
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Once results of a project are published, the project is moved to Publications.

General:

• Analysing adenovirus interaction with Kupffer cells 
  Submitted by Stuart Nicklin  (University of Glasgow, Glasgow, United Kingdom) 6/1/2009
  We wish to deplete the liver of Kupffer cells to study interactions with adenoviruses



• Macrophage inhinibition 
  Submitted by HELENE TE  (Novartis Pharma AG, Basel, Switzerland) 6/1/2009
  Study of macrophage inhibition



• Role of monocytes/macrophages in resorption of blood coagulum and thrombus 
  Submitted by Tetsuro Yamamoto  (Kumamoto University, Kumamoto City, Japan) 5/1/2009
  To examine the role of monocytes/macrophages in resorption of thrombotic diseases, we have recently established an animal experimental model in which coagulated guinea pig blood was inserted into the peritoneal cavity and the fate of coagula was observed quantitatively and morphologically. In this model, we have observed that the coagula resorption period was significantly reduced by making peripheral monocytotic state in the guinea pig using macrophage colony stimulating factor. Now, we'd like to see the effect of macrophage depletion on the coagula resorption in the guinea pig model.



• Role of inflammation in sensory axon regeneration 
  Submitted by Byung Kim  (Ajou University School of Medicine, Suwon, Korea, South) 12/30/2008
  The aim of the project is to examine a possible role of macrophages in the DRGs to augment regenerative reponse of sensory axon regeneration. Clodronateliposomes will be used to deplete infiltrating macrophages in the DRGs to see if the macrophages are required for the iincrease of regenerative capacity of sensory neurons.



• Effect of Macrophage depletion on Kidney 
  Submitted by SUFYAN ALI SAYYED  (LMU, Munich, Germany) 12/17/2008
  We would like to evaluate the effect of total macrophage depletion on progression of nephropathy.



• FSI Liposome development 
  Submitted by YP Zhang  (FSI, Cupertino, United States) 12/13/2008
  Liposome encapsulation of water-insoluble compounds



• Kupffer Cell Depletion 
  Submitted by Young Hahn  (University of Virginia/Carter Immunology Center, Charlottesville, Virginia, United States) 10/12/2008
  Treat one experimental group of mice (n=3) with clodronate liposome one day prior to feeding a Methionine and Choline deficient diet (MCD). Another group of mice (n=3) will also be fed MCD diet but with no clodronate treatment. Subsequently, two other groups of mice (n=3/group) will be treated similarly but using a Control diet. After 10 days, livers will be harvested and blood drawn for ALT levels.



• Understanidng Kupffer cell mediated serum enzyme clearance 
  Submitted by Petra koza-Taylor  (Pfizer, Groton,, United States) 9/12/2008
  Will monitor serum enzymes in rats pre and post Kupffer cell depletion to determine if Kupffer cell depletion increases the half-lives of serum enzymes.



• Monocyte depletion in TNBS colitis 
  Submitted by Pieter van Lierop  (Erasmus MC Sophia, Rotterdam, Netherlands, The) 5/12/2008
  Depletion of monocytes during TNBS development.



• Humanized mouse model of WAS using RNA interference 
  Submitted by Véronique PARIETTI  (généthon france, France, France) 4/12/2008
  To test in vivo the role of WASp in human lymphoid development, we developed a humanized mouse model of WAS using RNA interference. To improve engraftment of CD34+ cells, depletion of macrophages with clodronate liposome will be needed.