Current Projects

This is a list of projects currently using Clodronate Liposomes.
To submit your own project to this list, click here.
To change a project you submitted earlier, please log in and return to this page.
Once results of a project are published, the project is moved to Publications.

• Monocytes control neutrophils in acute lung injury 
  Submitted by Emma Scholefield  (University of Edinburgh, Edinburgh, United Kingdom) 6/2/2012
  Peripheral blood monocytes have been implicated in the pathogenesis of acute lung injury but little is known of their contribution to ongoing neutrophil influx in the persistent phase of acute lung injury.



• The Role of Macrophages in S.aureus Brain Abcess 
  Submitted by Aldrich Amy   (University of Nebraska Medical Center, Omaha, NE , United States) 3/2/2012
  Our lab has developed a brain abscess mouse model that results from S.aureus infection. The formation of the fibrotic wall around the abscess is one of the key events that needs to occur in order to limit the spread of infection and decrease mortality. Recently we published that macrophages comprise this cell wall region, and that bone marrow derived cells were producing fibrosis-associated molecules. However, it is still not clear what role the macrophages themselves are playing in wall formation. To investigate this, we hope to inhibit macrophage influx into the brain by depleting them from the periphery throughout the course of infection using the liposome technique. If successful, we plan to study what impact this loss has on the formation of the fibrotic wall.



• Analysis of the Mechanism that mediates immune protection against respiratory virus infectioins by a novel vaccine 
  Submitted by Bert Schepens  (Ugent, zwijnaarde, Belgium) 3/2/2012
  We have developed a novel vaccine candidate for the Respiratory Syncytial Virus (RSV). Although immune serum of vaccinated mice, protects mice against infections, it cannot neutralize RSV in vitro. Therefore we want to investigate which immune cells are involved in immune protection



• Gata1 in dendritic cells 
  Submitted by Maaike Scheenstra  (Sanquin, Amsterdam, Netherlands, The) 2/2/2012
  Study the function of the transcription factor in the development and function of dendritic cells



• SOCS-/- macrophages in tumour growth 
  Submitted by Amy Fitzsimons  (Queen's University belfast, Belfast, Antrim, United Kingdom) 2/2/2012
  This project will assess whether SOCS deficient macrophages alter tumour growth rates.



• Erythrophagocytosis in hyal2-/- mouse 
  Submitted by CECILE ONCLINX  (FUNDP, Namur, Belgium) 2/2/2012
  To investigate whether or not the macrophages' depletion ameliorate the turn-over of the hyal2-/- red blood cells



• Leukocyte migration 
  Submitted by Youngmin Hyun  (University of Rochester, Rochester, NY, United States) 1/2/2012
  I study each how leukocyte subsets perform migration through HUVEC focusing on signaling pathway.



• Phagocytosis of apoptotic bodies in transplantation 
  Submitted by Melissa Yeung  (Brigham & Women's Hospital, Boston, MA, United States) 1/2/2012
  This project will examine the role of apoptotic cell uptake (iso vs allogeneic) in transplant tolerance



• Clodronate in Schistosoma Haematobium infected mice 
  Submitted by Kim Thai  (Stanford University, Stanford, CA, United States) 1/31/2012
  Clodronate in Schistosoma Haematobium infected mice



• Angiopoietin-induced neutrophil migration 
  Submitted by Mark Ariaans  (University of Sheffield, Sheffield, United Kingdom) 1/31/2012
  The aim of this study is to examine the effects of Ang-1 on neutrophil migration in vivo. The liposomes are used to determine whether the observed effects are as a result of direct action of Ang-1 on neutrophils or an indirect effect of macrophage stimulation.